E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease
| Autor: | Lan Hsin Wang, Nicholas E. Baker |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
mammary gland
sertoli cell GTPase-activating protein Cellular differentiation Repressor Biology Article General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Rett syndrome ID protein neuronal morphogenesis Fuchs corneal dystrophy Pitt-Hopkins syndrome pulmonary arterial hypertension Helix-Loop-Helix protein Basic Helix-Loop-Helix Transcription Factors Animals Humans cellular senescence development Molecular Biology E protein Regulation of gene expression Genetics disease congenital hydronephrosis cell-cycle regulation diabetes Basic helix-loop-helix Cell Differentiation DNA differentiation Cell Biology Cell cycle osteoporosis trophoblast arterial vascular disease Repressor Proteins schizophrenia Gene Expression Regulation chemistry Knockout mouse Parkinson’s disease Sjogren’s syndrome Inhibitor of Differentiation Proteins atherosclerosis Developmental Biology |
| Zdroj: | Developmental Cell. 35:269-280 |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/j.devcel.2015.10.019 |
| Popis: | The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous partners, the E-proteins. A widely-expressed class of inhibitory heterodimer partners- the Inhibitor of DNA-binding (ID) proteins- also exists. Genetic and molecular analyses in humans and in knockout mice implicate E-proteins and ID-proteins in a wide variety of diseases, belying the notion that they are non-specific partner proteins. Here, we explore relationships of E-proteins and ID-proteins to a variety of disease processes and highlight gaps in knowledge of disease mechanisms. |
| Databáze: | OpenAIRE |
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