Proportion of membrane proteins in proteomes of 15 single-cell organisms analyzed by the SOSUI prediction system
| Autor: | Seah Boon-Chieng, Mitsuo Ono, Shigeki Mitaku, Masashi Sonoyama, Takatsugu Hirokawa |
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| Rok vydání: | 2000 |
| Předmět: |
Genetics
education.field_of_study Bacteria Proteome Chemistry Organic Chemistry Population Biophysics Membrane Proteins Saccharomyces cerevisiae Biochemistry Archaea Transmembrane protein Transmembrane domain Open Reading Frames Membrane protein Artificial Intelligence SOSUI education Genome size Alpha helix Software |
| Zdroj: | Biophysical chemistry. 82(2-3) |
| ISSN: | 0301-4622 |
| Popis: | A software system, SOSUI, was previously developed for discriminating between soluble and membrane proteins and predicting transmembrane regions (Hirokawa et al., Bioinformatics, 14 (1998) 378–379). The performance of the system was 99% for the discrimination between two types of proteins and 96% for the prediction of transmembrane helices. When all of the amino acid sequences from 15 single-cell organisms were analyzed by SOSUI, the proportion of predicted polytopic membrane proteins showed an almost constant value of 15–20%, irrespective of the total genome size. However, single-cell organisms appeared to be categorized in terms of the preference of the number of transmembrane segments: species with small genomes were characterized by a significant peak at a helix number of approximately six or seven; species with large genomes showed a peak at 10 or 11 helices; and species with intermediate genome sizes showed a monotonous decrease of the population of membrane proteins against the number of transmembrane helices. |
| Databáze: | OpenAIRE |
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