Hepatoprotective Efficacy ofCichorium intybusL. Extract Against Carbon Tetrachloride-induced Liver Damage in Rats
Autor: | Doha H. Aboubaker, Souad E. El-Gengaihi, Abdel-Tawab H. Mossa, Amel A. Refaie |
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Rok vydání: | 2016 |
Předmět: |
Male
0301 basic medicine Phytochemicals Plant Roots Antioxidants Chicory law.invention chemistry.chemical_compound law Pharmacology (medical) Gamma-glutamyltransferase Carbon Tetrachloride Nutrition and Dietetics biology Traditional medicine Chemistry food and beverages Alanine Transaminase Organ Size gamma-Glutamyltransferase Liver Biochemistry Phytochemical Alkaline phosphatase Chemical and Drug Induced Liver Injury Silymarin Bilirubin 03 medical and health sciences Cichorium Toxicity Tests Acute Animals Aspartate Aminotransferases Serum Albumin 030102 biochemistry & molecular biology Plant Extracts Body Weight Polyphenols Alkaline Phosphatase biology.organism_classification Rats Plant Leaves 030104 developmental biology Alanine transaminase biology.protein Carbon tetrachloride Phytotherapy Biomarkers Food Science |
Zdroj: | Journal of Dietary Supplements. 13:570-584 |
ISSN: | 1939-022X 1939-0211 |
DOI: | 10.3109/19390211.2016.1144230 |
Popis: | The purpose of the study was to assess the phytochemical and hepatoprotective activity of different extracts of dried herb of Cichorium intybus L. against carbon tetrachloride (CCl4) intoxicated male albino rats. The hepatoprotective activity of different extracts at 500 mg/kg body weight was compared with carbon tetrachloride-treated animals. The animals were divided into five groups with six animals in each group. The first group represents control, the second group received carbon tetrachloride, the third received C. intybus, and the fourth group received C. intybus plus carbon tetrachloride. The fifth group received silymarin as hepato-slandered drug. There were significant changes in serum biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin, albumin, total protein, and γ-glutamyl transferase (GGT) in carbon tetrachloride intoxicated rats, which were restored towards normal values in C. intybus-treated animals. Histopathological examination of liver tissues further substantiated these findings. In conclusion, of this investigation, the results ascertain that the herb extracts of C. intybus possess significant hepatoprotective activity. |
Databáze: | OpenAIRE |
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