Hepatoprotective Efficacy ofCichorium intybusL. Extract Against Carbon Tetrachloride-induced Liver Damage in Rats

Autor: Doha H. Aboubaker, Souad E. El-Gengaihi, Abdel-Tawab H. Mossa, Amel A. Refaie
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Phytochemicals
Plant Roots
Antioxidants
Chicory
law.invention
chemistry.chemical_compound
law
Pharmacology (medical)
Gamma-glutamyltransferase
Carbon Tetrachloride
Nutrition and Dietetics
biology
Traditional medicine
Chemistry
food and beverages
Alanine Transaminase
Organ Size
gamma-Glutamyltransferase
Liver
Biochemistry
Phytochemical
Alkaline phosphatase
Chemical and Drug Induced Liver Injury
Silymarin
Bilirubin
03 medical and health sciences
Cichorium
Toxicity Tests
Acute

Animals
Aspartate Aminotransferases
Serum Albumin
030102 biochemistry & molecular biology
Plant Extracts
Body Weight
Polyphenols
Alkaline Phosphatase
biology.organism_classification
Rats
Plant Leaves
030104 developmental biology
Alanine transaminase
biology.protein
Carbon tetrachloride
Phytotherapy
Biomarkers
Food Science
Zdroj: Journal of Dietary Supplements. 13:570-584
ISSN: 1939-022X
1939-0211
DOI: 10.3109/19390211.2016.1144230
Popis: The purpose of the study was to assess the phytochemical and hepatoprotective activity of different extracts of dried herb of Cichorium intybus L. against carbon tetrachloride (CCl4) intoxicated male albino rats. The hepatoprotective activity of different extracts at 500 mg/kg body weight was compared with carbon tetrachloride-treated animals. The animals were divided into five groups with six animals in each group. The first group represents control, the second group received carbon tetrachloride, the third received C. intybus, and the fourth group received C. intybus plus carbon tetrachloride. The fifth group received silymarin as hepato-slandered drug. There were significant changes in serum biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin, albumin, total protein, and γ-glutamyl transferase (GGT) in carbon tetrachloride intoxicated rats, which were restored towards normal values in C. intybus-treated animals. Histopathological examination of liver tissues further substantiated these findings. In conclusion, of this investigation, the results ascertain that the herb extracts of C. intybus possess significant hepatoprotective activity.
Databáze: OpenAIRE