Correlation Between Intracranial Arterial Calcification and Imaging of Cerebral Small Vessel Disease
| Autor: | Yuan-Chang Chen, Yuehua Li, Xiao-Er Wei, Xue-Feng Shen, Jing Lu, Rui-Hua Qiao |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
030204 cardiovascular system & hematology lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Internal medicine intracranial arterial calcification medicine magnetic resonance imaging lcsh:Neurology. Diseases of the nervous system intracranial arterial disease Computed tomography angiography Original Research medicine.diagnostic_test Cerebral infarction business.industry cerebral small vessel disease Intracranial Artery Magnetic resonance imaging medicine.disease Hyperintensity Arterial calcification Neurology Angiography Cardiology Neurology (clinical) business computed tomography angiography 030217 neurology & neurosurgery Calcification |
| Zdroj: | Frontiers in Neurology Frontiers in Neurology, Vol 10 (2019) |
| ISSN: | 1664-2295 |
| Popis: | Background and Purpose: Vascular calcification is part of the atherosclerotic process. Intracranial artery calcification is closely associated with cerebral small vessel disease (SVD). The present study aimed to investigate the distribution pattern of intracranial arterial calcification and its association with magnetic resonance imaging (MRI) markers of SVD in patients with acute ischemic cerebrovascular disease. Methods: Two hundred and seventy six consecutive patients with transient ischemic attack (TIA) or acute ischemic stroke who underwent both computed tomography (CT) angiography and MRI were enrolled in this study. Intracranial arterial calcium scores were evaluated using Agatston method. MRI was performed to assess cerebral infarction, white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVSs). Results: Intracranial artery calcification was present in 200 (72.46%) patients, with the highest prevalence in the internal carotid arteries (ICA) (64.8%). The severity of intracranial arterial calcification was associated with the presence of WMHs (P = 0.0001), lacunes (P = 0.0001), and CMBs (P = 0.0001); however, there was no association between calcifications and the presence of EPVSs (P = 0.058). The correlation coefficients (rs) were 0.350, 0.142, 0.285, and 0.251 for WMHs, EPVSs, lacunes, and CMBs, respectively. The adjusted odds ratios (ORs) of intracranial arterial calcification were: 2.747 for WMH (grade 1-2), 3.422 for WMH (grade 3), 2.902 for lacunes, 2.449 for CMB, 0.88 for EPVS (grade 1), and 0.295 for EPVS (grade 2-4). Conclusion: Intracranial artery calcification is common in patients with ischemic cerebrovascular disease and the intracranial carotid artery is most frequently affected. Intracranial arterial calcifications might be associated with imaging markers of SVD and are highly correlated with WMHs, lacunes, and CMBs. Quantification of calcification on CT provides additional information on the pathophysiology of SVD. Intracranial arterial calcification could act as a potential marker of SVD. |
| Databáze: | OpenAIRE |
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