Variants in COMT and DBH influence on response inhibition ability in Chinese Han females
| Autor: | Tianbao Yao, Wanyu Chi, Jian Wang, Kejin Zhang, Fuchang Zhang, Xiaocai Gao, Jing Li, Pingyuan Gong |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Genotype Dopamine Population Female group Dopamine beta-Hydroxylase Neuropsychological Tests Catechol O-Methyltransferase Cellular and Molecular Neuroscience Young Adult Chinese han population Asian People Internal medicine medicine Ethnicity Humans Chinese han education Gene Response inhibition education.field_of_study Catechol-O-methyl transferase Polymorphism Genetic Cell Biology General Medicine Inhibition Psychological Endocrinology Female Psychology medicine.drug |
| Zdroj: | Cellular and molecular neurobiology. 31(8) |
| ISSN: | 1573-6830 |
| Popis: | Catechol-O-methyltransferase (COMT) and dopamine-beta hydroxylase (DBH) are key enzymes to breakdown dopamine. Some previous studies have indicated that val158met in COMT and 19 bp insertion/deletion in 5′ flank of DBH are related to the performance of executive function. To further investigate the associations of the two genes with executive function, we performed a population-based study in a Chinese Han population. The results indicated that val158met in COMT and the 19 bp insertion/deletion of DBH were associated with the average reaction time of response inhibition in female group (P = 0.01, P = 0.03), respectively. Furthermore, there was a significant interaction of the two genes on the reaction time (P = 0.006). This present study suggests that not only do COMT and DBH influence independently on response inhibition in females, but also exert a significant interaction on response inhibition. |
| Databáze: | OpenAIRE |
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