New gender-specific formulae for estimating extracellular fluid volume from height and weight in adults
Autor: | A. Michael Peters, Nicholas J. Bird |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male medicine.medical_specialty Population Body water Urology Renal function Kidney Function Tests urologic and male genital diseases Kidney transplant 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Extracellular fluid medicine Humans Radiology Nuclear Medicine and imaging education reproductive and urinary physiology Body surface area Sex Characteristics education.field_of_study urogenital system business.industry Body Weight Extracellular Fluid General Medicine Middle Aged Body Height female genital diseases and pregnancy complications Single centre 030220 oncology & carcinogenesis Lean body mass Female business Glomerular Filtration Rate |
Zdroj: | Nuclear Medicine Communications. 42:58-62 |
ISSN: | 0143-3636 |
DOI: | 10.1097/mnm.0000000000001301 |
Popis: | Aims First, to derive gender-specific formulae for estimation of extracellular fluid volume (eECV) and second, compare eECV as a scaling metric for slope-intercept glomerular filtration rate (GFR) with estimated body surface area (eBSA), lean body mass (eLBM) and total body water (eTBW). Methods GFR and 'slope-only' GFR (GFR/ECV), both single compartment-corrected, were measured in a previously published multicentre database of healthy potential kidney transplant donors. Measured ECV (mECV) was obtained as ratio GFR-to-GFR/ECV. Formulae for eECV in men and women were derived from the relationship of mECV with height and weight and expressed as eECV = a.weight.height. In a population of prospective kidney transplant donors from a single centre, eECV was compared with mECV. GFR was scaled to eECV, eBSA, eLBM and eTBW, estimated from previously published formulae. Results In men and women, respectively, a was 0.0755 and 0.0399, x was 0.6185 and 0.6065 and y was 0.4982 and 0.6217. In the single centre, biases (±precisions) of eECV against mECV in men and women were 0.26 (±1.68) and 0.31 (±1.67) l. Mean GFR/eBSA was higher in men but mean GFR/eLBM and GFR/eTBW were higher in women. Mean GFR/ECV and mean GFR/eECV were very similar between the two genders. GFR/ECV and GFR/eECV showed correlations with each other that were almost identical between men and women. Conclusions New formulae are described for estimating eECV. Scaling GFR to eECV is more physiological than scaling to eBSA and accounts for gender. eECV used for measuring GFR from a single blood sample should be gender-specific. |
Databáze: | OpenAIRE |
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