Colony-stimulating factor-1 in primary ascites of ovarian cancer is a significant predictor of survival
| Autor: | Peter E. Schwartz, Joseph T. Chambers, Fredric V. Price, Maria Luisa Carcangiu, Ernest I. Kohorn, Barry M. Kacinski, Setsuko K. Chambers, E.R. Stanley |
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| Rok vydání: | 1993 |
| Předmět: |
Macrophage colony-stimulating factor
Oncology Adult Aging medicine.medical_specialty Ovary Gastroenterology Colony-Stimulating Factors Internal medicine Ovarian carcinoma Ascites medicine Carcinoma Humans Neoplasm Staging Ovarian Neoplasms Epithelioma business.industry Proportional hazards model Osmolar Concentration Obstetrics and Gynecology Radioimmunoassay General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Surgery medicine.anatomical_structure Multivariate Analysis Regression Analysis Female medicine.symptom business Ovarian cancer |
| Zdroj: | American Journal of Obstetrics and Gynecology. 168:520-527 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/0002-9378(93)90485-2 |
| Popis: | Our purpose was to determine whether the concentration of colony-stimulating factor in ascites of ovarian carcinoma is a prognostic factor for survival.Forty-four ascites samples from patients undergoing primary surgery for ovarian carcinoma were measured for colony-stimulating factor-1 by radioimmunoassay. Retrospective analysis of clinical data allowed comparison of accepted prognostic factors to ascites colony-stimulating factor-1 concentration for impact on survival by means of life-table analysis (Kaplan-Meier) by the Wilcoxon test and the Cox regression methods.In patients with advanced disease (International Federation of Gynecology and Obstetrics stages III and IV, n = 37) ascites colony-stimulating factor-1 concentration levels below a critical cutoff of 8.59 ng/ml were associated with longer overall survival (p0.05) and were a better predictor of survival than any other prognostic factor except zero residual disease after cytoreduction. International Federation of Gynecology and Obstetrics stage, tumor histologic type, malignant cells in fluid, grade of tumor, age, and performance status at presentation were not predictive of outcome.Colony-stimulating factor-1 in ascites may be an independent indicator of prognosis in patients with epithelial ovarian cancer. |
| Databáze: | OpenAIRE |
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