Effect of antioxidants and antibiotics on levels of seminal oxidative stress in leukocytospermic infertile men

Autor:	Sunil B. Yadav, Adinath N. Suryakar, Anil D. Huddedar, P. S. Shukla
Rok vydání:	2006
Předmět:	Infertility endocrine system urogenital system Clinical Biochemistry Semen Biology medicine.disease Ferric reducing ability of plasma Sperm Article Nitric oxide Andrology chemistry.chemical_compound chemistry Griess test medicine Nitrite Sperm motility
Zdroj:	Indian Journal of Clinical Biochemistry. 21:152-156
ISSN:	0974-0422 0970-1915
DOI:	10.1007/bf02913085
Popis:	Defective sperm function is the most common cause of infertility. A prospective study was carried out to correlate the concentration of nitrite (the stable metabolite of nitric oxide) in seminal plasma with leukocytospermia, and sperm membrane integrity. Total Fifty-seven normozoospermic subjects with and without leukocytospermia visiting the Infertility clinic at KH and MRC, Karad, were included in the present study. Semen samples were checked for sperm concentration, total sperm count, sperm motility, seminal leukocyte concentration and sperm membrane integrity as Hypoosmotic Swelling Test. Similarly the concentration of nitrite in seminal plasma was measured by Griess reaction and total antioxidant power measured as ferric reducing ability of plasma. The concentration of nitrite in seminal plasma was found to be raised with significantly increased leukocyte concentration in semen. Also significantly lowered levels of total antioxidant power along with defective sperm function was observed. Our results suggest that supplementary treatment of antioxidants with antibiotic for leukocytospermic infertile male patients may improve the sperm membrane integrity.
Databáze:	OpenAIRE
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