Effects of Lippia citriodora Leaf Extract on Lipid and Oxidative Blood Profile of Volunteers with Hypercholesterolemia: A Preliminary Study
| Autor: | Francesco Vizzarri, Carlo Corino, Deborah Leccese, Antonella Angiolillo, Alfonso Di Costanzo, Marisa Palazzo, Donato Vito Casamassima |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Vitamin Antioxidant Physiology medicine.medical_treatment Clinical Biochemistry Blood lipids 030204 cardiovascular system & hematology Pharmacology verbascoside Biochemistry Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Molecular Biology Lippia biology medicine.diagnostic_test hypercholesterolemia Chemistry Vitamin E lcsh:RM1-950 Cell Biology biology.organism_classification Malondialdehyde Ferric reducing ability of plasma 030104 developmental biology antioxidants lcsh:Therapeutics. Pharmacology Antioxidants Hypercholesterolemia Verbascoside Lipid profile |
| Zdroj: | Antioxidants, Vol 10, Iss 521, p 521 (2021) Antioxidants Volume 10 Issue 4 |
| ISSN: | 2076-3921 |
| Popis: | Lippia citriodora is a plant traditionally used for its anti-inflammatory, antioxidant and antispasmodic effects, as well as for additional biological activities proven in cell culture, animal studies and a small number of human clinical trials. The plant has also shown a marked improvement in blood lipid profile in some animal species. In the present preliminary study, we investigated the effect of a leaf extract on lipid and oxidative blood profile of hypercholesterolemic volunteers. Twelve adults received Lippia citriodora extract caps, containing 23% phenylpropanoids, (100 mg, once a day) for 16 weeks. Selected blood lipids and plasma oxidative markers were measured at baseline and after 4, 8 and 16 weeks of treatment. Compared with baseline, total cholesterol levels significantly decreased and high-density lipoprotein cholesterol increased, while low-density lipoprotein cholesterol and triglycerides showed only a downward trend. Oxidative status was improved due to a decrease in the concentration of total oxidant status, reactive oxygen metabolites and malondialdehyde, and a significant increase in ferric reducing ability of plasma, vitamin A and vitamin E. These preliminary results suggest that dietary supplementation with Lippia citriodora extract can improve the lipid profile, enhance blood antioxidant power, and could be a valuable natural compound for the management of human hypercholesterolemia. |
| Databáze: | OpenAIRE |
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