Factors Associated with Mother-to-child Transmission of Hepatitis B Virus Despite Immunoprophylaxis
| Autor: | Lan-Lan Chen, Cui-Ping Liu, Hong Tang, Li Wang, Yi-lan Zeng, Rong Hu, Min Zhou |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Hepatitis B virus medicine.medical_specialty HBsAg Time Factors Immunoglobulins medicine.disease_cause Antiviral Agents Young Adult Pregnancy Risk Factors Internal Medicine medicine Humans Hepatitis B e Antigens Pregnancy Complications Infectious Hepatitis B Surface Antigens Obstetrics Vaginal delivery business.industry Immunization Passive Infant Newborn Infant virus diseases General Medicine Odds ratio Viral Load Hepatitis B medicine.disease Infectious Disease Transmission Vertical Logistic Models HBeAg Child Preschool Multivariate Analysis Female business Viral load Follow-Up Studies |
| Zdroj: | Internal Medicine. 54:711-716 |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | OBJECTIVE: This study aimed to assess risk factors for mother-to-child transmission (MTCT) of hepatitis B virus (HBV) after immunoprophylaxis. METHODS: Risk factors for MTCT were assessed using a multivariate logistic regression model. PATIENTS: We enrolled 256 mother-child pairs with positive maternal hepatitis B surface antigens (HBsAg) between January 2010 and June 2013. All children received passive-active immunization after birth. The children were tested for HBsAg at birth and 6-12 months and/or 1-3 years of age. RESULTS: Among 256 children, 10 (3.9%) developed HBV infection, all of whom were born to hepatitis B e antigen (HBeAg)-positive mothers with a high HBV DNA level (median, 7.36; range, 6.75-8.00 log10 IU/mL). A total of 20 mothers received antiviral treatment during pregnancy. The maternal viral load decreased from an average of 7.16 to 3.08 log10 IU/mL (p |
| Databáze: | OpenAIRE |
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