Painful diabetic neuropathy is associated with increased nerve regeneration in patients with type 2 diabetes undergoing intensive glycemic control

Autor: Ioannis N. Petropoulos, Ayman Megahed, Hanadi Al Hamad, Georgios Ponirakis, Fatema AlMarri, Hoda Gad, Rayaz A. Malik, Muhammad A. Abdul-Ghani, Hamad Almuhannadi, Adnan Khan, Osama Migahid, Amin Jayyousi, Marwan Ramadan, Salma Al-Mohannadi, Murtaza Qazi, Mahmoud Zirie, Fatima Al-Khayat, Ziyad Mahfoud, Ralph A. DeFronzo
Rok vydání: 2021
Předmět:
Blood Glucose
Male
Endocrinology
Diabetes and Metabolism
Type 2 diabetes
Cornea
chemistry.chemical_compound
Nerve Fibers
0302 clinical medicine
Diabetic Neuropathies
PDPN
Articles
General Medicine
Middle Aged
Prognosis
Clinical Trial
Clinical Science and Care
medicine.anatomical_structure
Anesthesia
Female
medicine.drug
Adult
Adolescent
Pain
030209 endocrinology & metabolism
Nerve fiber
Glycemic Control
Diseases of the endocrine glands. Clinical endocrinology
Young Adult
03 medical and health sciences
Vibration perception
Painful diabetic neuropathy
Diabetes mellitus
Internal Medicine
medicine
Humans
Hypoglycemic Agents
Qatar
Aged
Glycated Hemoglobin
business.industry
RC648-665
medicine.disease
Nerve Regeneration
Peripheral neuropathy
Diabetes Mellitus
Type 2
chemistry
Corneal confocal microscopy
Case-Control Studies
Exenatide
sense organs
Glycated hemoglobin
business
Pioglitazone
Biomarkers
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 12, Iss 9, Pp 1642-1650 (2021)
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.13544
Popis: Aims/Introduction Painful diabetic peripheral neuropathy (pDPN) is associated with small nerve fiber degeneration and regeneration. This study investigated whether the presence of pDPN might influence nerve regeneration in patients with type 2 diabetes undergoing intensive glycemic control. Materials and Methods This exploratory substudy of an open‐label randomized controlled trial undertook the Douleur Neuropathique en 4 questionnaire and assessment of electrochemical skin conductance, vibration perception threshold and corneal nerve morphology using corneal confocal microscopy in participants with and without pDPN treated with exenatide and pioglitazone or basal–bolus insulin at baseline and 1‐year follow up, and 18 controls at baseline only. Results Participants with type 2 diabetes, with (n = 13) and without (n = 28) pDPN had comparable corneal nerve fiber measures, electrochemical skin conductance and vibration perception threshold at baseline, and pDPN was not associated with the severity of DPN. There was a significant glycated hemoglobin reduction (P
There has been a resurgence of interest in identifying new drug targets or, predictive biomarkers of disease‐modifying therapies in diabetic neuropathy. We show that the presence of painful diabetic neuropathy was associated with greater corneal nerve regeneration and an improvement in painful neuropathic symptoms in patients with type 2 diabetes undergoing intensive glycemic control.
Databáze: OpenAIRE
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