Elevated parathyroid hormone-related protein and hypercalcemia in two dogs with schistosomiasis
| Autor: | A M Braniecki, T M Craig, Kenita S. Rogers, J M Fradkin, Debra L. Zoran, F Ramiro-Ibanez |
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| Rok vydání: | 2001 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Pathology Anemia Hyperglobulinemia Schistosomiasis Anorexia Malignancy Gastroenterology Diagnosis Differential Dogs Internal medicine medicine Animals Eosinophilia Dog Diseases Hypoalbuminemia Vitamin D Small Animals Parathyroid hormone-related protein business.industry Parathyroid Hormone-Related Protein Proteins medicine.disease Parathyroid Hormone Hypercalcemia Female medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of the American Animal Hospital Association. 37:349-355 |
| ISSN: | 1547-3317 0587-2871 |
| Popis: | Two adult dogs were evaluated for hypercalcemia. Diagnostic evaluation identified elevated parathyroid hormone-related protein (PTHrP) and presumptive humoral hypercalcemia of malignancy. At necropsy, schistosomiasis was diagnosed. North American schistosomiasis is caused by Heterobilharzia americana. Clinical findings may include dermatitis, coughing, diarrhea, and anorexia. Clinicopathological findings may include hypercalcemia, hyperglobulinemia, hypoalbuminemia, anemia, and eosinophilia. Diagnosis by fecal examination is difficult. Praziquantel or fenbendazole treatment may be curative or palliative. These are the first reported cases of hypercalcemia with elevated PTHrP in animals without diagnosed malignancy. Elevation of PTHrP has not been previously reported in hypercalcemic humans or in animals with granulomatous inflammation. |
| Databáze: | OpenAIRE |
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