Imprinted gene in postnatal growth role
| Autor: | Marie-Christine Multon, François Dautry, Jean-Michel Itier, V Cormier, Gunter Tremp, Gwénaëlle Ret, Marie-Thérèse Bluet-Pajot, Fabien Schweighoffer, Bruno Tocque, Jean-François Léonard |
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| Rok vydání: | 1998 |
| Předmět: |
Genetics
Male Multidisciplinary Regulator Hypothalamus Gene targeting A protein Growth Biology Growth hormone DNA-Binding Proteins Genomic Imprinting Mice Growth Hormone Pituitary Gland Gene Targeting Animals Female Postnatal growth Insulin-Like Growth Factor I Genomic imprinting Gene Function (biology) |
| Zdroj: | Nature. 393(6681) |
| ISSN: | 0028-0836 |
| Popis: | Mice that have been specially bred to lack a protein known as Grf-1, which is normally found only in the brain, do not grow properly after they are born and remain small all their lives. We have now identified a function of Grf-1 as an important regulator of the synthesis and release of growth hormone. Moreover, grf1, the gene encoding this protein, is unlike other imprinted genes that affect growth because it operates after, rather than before, birth. |
| Databáze: | OpenAIRE |
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