Preserved CO2response in cerebral and muscular blood vessels during cimetidine treatment
| Autor: | Denise Hartemann, Claude Saunier, O. Bigard, P. Amend, A. Sautegeau, C. Alvernhe, Gérard Audibert |
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| Rok vydání: | 1991 |
| Předmět: |
Physiology
medicine.medical_treatment Hemodynamics Hypercapnia Dogs Cerebellum medicine Animals Cimetidine Saline Inhalation business.industry Muscles General Medicine Blood flow Carbon Dioxide Hypoxia (medical) Microspheres Oxygen Cerebral blood flow Regional Blood Flow Anesthesia Blood Vessels Blood Gas Analysis medicine.symptom business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Clinical Physiology. 11:367-373 |
| ISSN: | 1365-2281 0144-5979 |
| DOI: | 10.1111/j.1475-097x.1991.tb00665.x |
| Popis: | It is known that cimetidine inhibits the hypoxia-induced increase in cerebral blood flow (CFB) in dogs, but the mechanism of this inhibition is not fully understood. Since the accepted mechanisms explaining the increase in CBF during hypercapnia are very different from those active during hypoxia, acute hypercapnia was induced in 12 conscious dogs in order to study the cimetidine effect in this condition. Six dogs were given i.v. saline (control group) and the other six, i.v. cimetidine (4 mg kg-1). After 15 min, CBF and various muscular blood flow measurements were performed, using the microspheres technique under two conditions: (1) breathing air and (2) after 2 h inhalation of a gas mixture with FiCO2 0.10, FiO2 0.21 in nitrogen. The CBF increase was similar in both series with or without cimetidine. The changes in muscular blood flow were unaffected by the H2-blocker. We conclude that cimetidine has no effect on the CBF and on muscular blood flow during acute hypercapnia. |
| Databáze: | OpenAIRE |
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