Entamoeba histolytica L220 induces the in vitro activation of macrophages and neutrophils and is modulated by neurotransmitters
| Autor: | Rogelio Salinas-Gutiérrez, Verónica-Ivonne Hernández-Ramírez, Mario García-Lorenzana, Javier Ventura-Juárez, Patricia Talamás-Rohana, Martín Humberto Muñoz-Ortega, Galileo Escobedo, Fabiola Del Rocío Villalobos-Gómez, Esperanza Sánchez-Alemán, María del Rosario Campos-Esparza |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Nicotine Adolescent Epinephrine Neutrophils medicine.medical_treatment Protozoan Proteins Inflammation Stimulation Neutrophil Activation Microbiology Young Adult 03 medical and health sciences Entamoeba histolytica 0302 clinical medicine Immune system Lectins medicine Humans Secretion Neurotransmitter Agents Vecuronium Bromide biology Macrophages Macrophage Activation biology.organism_classification In vitro 030104 developmental biology Cytokine Cytokines Cholinergic Parasitology medicine.symptom 030217 neurology & neurosurgery |
| Zdroj: | Acta Parasitologica. 63:270-279 |
| ISSN: | 1896-1851 1230-2821 |
| DOI: | 10.1515/ap-2018-0031 |
| Popis: | The neuroimmunoregulation of inflammation has been well characterized. Entamoeba histolytica provokes an inflammatory response in the host in which macrophages and neutrophils are the first line of defense. The aim of this study was to analyze the effect of the 220 kDa lectin of Entamoeba histolytica on stimulation of human macrophages and neutrophils, especially the secretion of cytokines and the relation of these to neurotransmitters. Human cells were interacted with L220, epinephrine, nicotine, esmolol and vecuronium bromide. The concentrations of IL-1β, IFN-γ, TNF-α and IL-10 were determined by ELISA at, 4 h of interaction. L220 has a cytokine stimulating function of macrophages and neutrophils for secretion of IL-1β, and IL-10 only by macrophages, which was modulated by the effect of vecuronium on cholinergic receptors in this immune cells. |
| Databáze: | OpenAIRE |
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