Dietary Compounds To Reduce In Vivo Inorganic Arsenic Bioavailability
| Autor: | Vicenta Devesa, María Jesús Clemente, Dinoraz Vélez, Alessandra Cimbalo, Gabriela de Matuoka e Chiocchetti |
|---|---|
| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil) |
| Rok vydání: | 2019 |
| Předmět: |
Male
0106 biological sciences Bioavailability Inorganic arsenic Biological Availability chemistry.chemical_element Food Contamination Ferric Compounds 01 natural sciences Arsenicals Dietary Exposure Excretion Mice chemistry.chemical_compound In vivo Tannic acid Animals Ingestion Food science Lung Arsenic Mice Inbred BALB C Fecal excretion 010401 analytical chemistry Oryza General Chemistry Glutathione Tissue accumulation 0104 chemical sciences Liver chemistry General Agricultural and Biological Sciences Iron salts 010606 plant biology & botany |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | It is estimated that approximately 200 million people are exposed to arsenic levels above the World Health Organization provisional guideline value, and various agencies have indicated the need to reduce this exposure. In view of the difficulty of removing arsenic from water and food, one alternative is to reduce its bioavailability (the amount that reaches the systemic circulation after ingestion). In this study, dietary components [glutathione, tannic acid, and Fe(III)] were used to achieve this goal. As(III) or As(V) (1 mg/kg body weight) was administered daily to BALB/c mice, along with the dietary components, for 15 days. The results confirm the efficacy of Fe(III) and glutathione as reducers of arsenic bioavailability and tissue accumulation. Also, these treatments did not result in reductions of Ca, K, P, and Fe contents in the liver. These data suggest that use of these two compounds could be part of valid strategies for reducing inorganic arsenic exposure in chronically exposed populations. This work was supported by the Spanish Ministry of Economy and Competitiveness (AGL2015-68920-R) for which the authors are deeply indebted. Gabriela de Matuoka e Chiocchetti received a fellowship from the Brazilian Government (CAPES- BEX1086/14-6) to carry out this study. |
| Databáze: | OpenAIRE |
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