Single-prolonged stress activates the transcription factor ATF6α branch of the unfolded protein response in rat neurons of dorsal raphe nucleus
| Autor: | F. Han, Juhua Xie, Yuxiu Shi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Dorsal Raphe Nucleus
Male X-Box Binding Protein 1 medicine.medical_specialty XBP1 Clinical Biochemistry Gene Expression Regulatory Factor X Transcription Factors Stress Disorders Post-Traumatic Dorsal raphe nucleus Internal medicine medicine Animals Rats Wistar Molecular Biology Transcription factor Neurons Messenger RNA Membrane Glycoproteins Chemistry Endoplasmic reticulum Cell Biology General Medicine Transmembrane protein Activating Transcription Factor 6 Cell biology DNA-Binding Proteins Endocrinology Unfolded Protein Response Unfolded protein response Stress Psychological Transcription Factors |
| Zdroj: | Molecular and Cellular Biochemistry. 399:209-216 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/s11010-014-2247-4 |
| Popis: | In our previous studies, we have found that endoplasmic reticulum (ER) stress is associated with post-traumatic stress disorder (PTSD), however, the activation of ER stress sensors in PTSD remains unclear. ATF6 alpha (ATF6α) is an ER-membrane-bound transcription factor and functions as a critical sensor and regulator of ER stress in mammalian cells. The goal of this study is to detect whether there is activation of the transcription factor ATF6α branch of the unfolded protein response in the dorsal raphe nucleus neurons of the rats exposed to single-prolonged stress (SPS), which is a model employed extensively in PTSD study. Our results have demonstrated that SPS activated the ER transmembrane protein ATF6α via its cleavage; and induced the up-regulation of the downstream targets of ATF6α, the mRNA of XBP1 and GRP94. To the best of our knowledge, this is the first study to investigate the relationship between the ATF6α pathways and PTSD, and our results show that SPS activates the ATF6α branch of the ER stress response, which may be contributed to the pathogenesis of PTSD. |
| Databáze: | OpenAIRE |
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