Zizaane-Type Sesquiterpenoids and Their Rearranged Derivatives from Agarwood of an Aquilaria Plant
| Autor: | Jing-Zhe Yuan, Yi-Ling Yang, Wei Li, Li Yang, Hao-Fu Dai, Attila Mándi, Cai-Hong Cai, Hui-Qin Chen, Wen-Hua Dong, Tibor Kurtán, Wen-Li Mei, Hao Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Magnetic Resonance Spectroscopy
zizaane Chemical Phenomena Cell Survival Anti-Inflammatory Agents Pharmaceutical Science Organic chemistry Article Analytical Chemistry Mice QD241-441 TDDFT-ECD Drug Discovery Animals Physical and Theoretical Chemistry agarwood Aquilaria sp sesquiterpenoid anti-inflammatory effect Molecular Structure Wood RAW 264.7 Cells Chemistry (miscellaneous) Thymelaeaceae Molecular Medicine Sesquiterpenes |
| Zdroj: | Molecules, Vol 27, Iss 198, p 198 (2022) Molecules Molecules; Volume 27; Issue 1; Pages: 198 |
| ISSN: | 1420-3049 |
| Popis: | Nine new sesquiterpenoids (1–9) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp., including three novel sesquiterpenoids (1–3) derived from zizaane, together with six zizaane-type sesquiterpenoids (4–9). All structures were unambiguously elucidated based on 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of sesquiterpenoids was determined by comparison of the experimental and computed ECD spectra. In vitro anti-inflammatory assessment showed that compound 9 exhibited inhibition of NO production in LPS-stimulated RAW264.7 cells with an IC50 value of 62.22 ± 1.27 μM. |
| Databáze: | OpenAIRE |
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