Study of oxidative-stress in rifampicin-induced hepatic injury in growin rats with and without protein-energy malnutrition
| Autor: | Chhinder P. Sodhi, Satish Mehta, Satyavati Rana, Saroj Mehta, R. C. Goel, Kim Vaiphei |
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| Rok vydání: | 1997 |
| Předmět: |
Male
0301 basic medicine Health Toxicology and Mutagenesis medicine.medical_treatment Intraperitoneal injection Oxidative phosphorylation Pharmacology Toxicology medicine.disease_cause Protein-Energy Malnutrition Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Aspartate Aminotransferases Rats Wistar Serum Albumin Glutathione Transferase Antibacterial agent Glutathione Peroxidase 030102 biochemistry & molecular biology biology Superoxide Dismutase Alanine Transaminase Bilirubin General Medicine Glutathione Catalase Rats Oxidative Stress Glutathione Reductase Liver Biochemistry chemistry 030220 oncology & carcinogenesis Toxicity biology.protein Lipid Peroxidation Rifampin Oxidative stress |
| Zdroj: | Human & Experimental Toxicology. 16:315-321 |
| ISSN: | 1477-0903 0960-3271 |
| Popis: | 1 Rifampicin (RMP) induced hepatic injury was investi gated in growing rats. The interaction of moderate and severe protein-energy malnutrition (PEM) was also investigated. 2 Status of oxidative/antioxidative profile was studied by the mechanistic approach, to enumerate the nature of injury. 3 Successful hepatic injury in rats was produced by giving intraperitoneal injection of RMP (50 mg/kg/ day). 4 Hepatic lipid peroxidation was significantly increased in all the RMP treated rats. 5 Superoxide dismutase, catalase and glutathione per oxidase activities in the hepatic tissue decreased with RMP treatment. 6 Hepatic thiols represented as total and protein-bound thiols, showed significant elevation, whereas the non protein thiols remain unchanged with RMP treatment. 7 Glutathione-S-transferases also showed significant elevation against 1,2-dichloro-4 nitrobenzene (DCNB) and ethacrynic acid (EA) as substrates. 8 The oxidative/antioxidative profile was observed to be more severely affected with coexistence of malnutri tion. 9 Histopathological correlation showed an additional fatty infiltration of hepatocytes with coexistence of malnutrition. 10 Thus, in conclusion, it can be speculated that an altered oxidative/antioxidative profile is the closely associated with production of RMP induced hepatic injury. |
| Databáze: | OpenAIRE |
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