Aerogel from chemo-enzymatically oxidized fenugreek gum: an innovative delivery system of isothiazolinones biocides
| Autor: | Luca Merlini, Milena Brasca, Yves M. Galante, Tiziana Silvetti |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Isothiazolinones ù
Biocide Fenugreek media_common.quotation_subject Gingiva 02 engineering and technology Microbial Sensitivity Tests 010402 general chemistry 01 natural sciences Applied Microbiology and Biotechnology Cosmetics Activity spectrum Delivery systems media_common Drug Carriers Aqueous solution Bacteria Chemistry Aerogels Biomaterial Aerogel General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Laccase oxidation Trigonella Delivery system 0210 nano-technology Gels Biotechnology Nuclear chemistry Disinfectants |
| Zdroj: | Applied microbiology and biotechnology 102 (2018): 2683–2692. doi:10.1007/s00253-018-8804-0 info:cnr-pdr/source/autori:Silvetti, Tiziana; Merlini, Luca; Brasca, Milena; Galante, Yves M/titolo:Aerogel from chemo-enzymatically oxidized fenugreek gum: an innovative delivery system of isothiazolinones biocides./doi:10.1007%2Fs00253-018-8804-0/rivista:Applied microbiology and biotechnology/anno:2018/pagina_da:2683/pagina_a:2692/intervallo_pagine:2683–2692/volume:102 |
| ISSN: | 1432-0614 |
| DOI: | 10.1007/s00253-018-8804-0 |
| Popis: | Aerogels of chemo-enzymatically oxidized, lyophilized fenugreek gum (EOLFG) were evaluated as “delivery system” (DS) of the microbiocide mix 5-chloro-2-methyl-4-isothiazolin-3-one (CIT) and 2-methyl-4-isothiazolin-3-one (MIT). These biocides have a broad activity spectrum and a low MIC (minimal inhibitory concentration) in the ppm range. They are approved under the EU Biocidal Product Directive for various applications, including cosmetics, are classified as skin sensitizers, and are under increasing scrutiny to limit or eliminate their use. We demonstrate that CIT/MIT can be uptaken into EOLFG aerogel corks by immersion into aqueous solutions of microbiocides, followed by blotting and re-lyophilization to generate “loaded” EOLFG aerogels. Incubation of “loaded” corks in water brings about a slow and almost complete release of the absorbed actives having the same MIC of free biocides against selected bacterial pathogens. This new biomaterial could represent an innovative DS of microbiocides and other actives for a variety of industrial, food, cosmetic, and biomedical applications. |
| Databáze: | OpenAIRE |
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