Chitosan-pluronic based Cu nanocomposite hydrogels for prototype antimicrobial applications

Autor: Ali Akbari-Fakhrabadi, Radha D. Pyarasani, John Amalraj, Tippabattini Jayaramudu, K. Koteshwara Reddy, Kokkarachedu Varaprasad
Rok vydání: 2020
Předmět:
Thermogravimetric analysis
Materials science
Chemical Phenomena
Scanning electron microscope
Metal Nanoparticles
Nanogels
Nanoparticle
Chemistry Techniques
Synthetic
Microbial Sensitivity Tests
macromolecular substances
02 engineering and technology
engineering.material
Biochemistry
Nanocomposites
Chitosan
03 medical and health sciences
chemistry.chemical_compound
Anti-Infective Agents
X-Ray Diffraction
Structural Biology
Spectroscopy
Fourier Transform Infrared
Escherichia coli
Fourier transform infrared spectroscopy
Molecular Biology
030304 developmental biology
0303 health sciences
Precipitation (chemistry)
technology
industry
and agriculture
General Medicine
Poloxamer
021001 nanoscience & nanotechnology
Chemical engineering
chemistry
Thermogravimetry
engineering
Biopolymer
0210 nano-technology
Copper
Zdroj: International Journal of Biological Macromolecules. 143:825-832
ISSN: 0141-8130
Popis: Copper nanoparticles were synthesized via precipitation technique using the pseudonatural cationic chitosan biopolymer as a stabilizing agent. The nanoparticles developed were successfully incorporated into the 1:1 ratio of blended chitosan: pluronic F127 polymer solution and made their nanocomposite hydrogels by solution casting method. The formed copper-based nanocomposite hydrogels were characterized by using Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, scanning electron microscopy-energy dispersive spectroscopy and transmission electron microscopy studies. The antimicrobial activity of the fabricated nanocomposite hydrogels was tested via an inhibition zone process against both E. coli (gram-negative) and S. aureus (gram-positive) bacteria. The results conveyed that the copper-embedded chitosan-pluronic\ F127 nanocomposite hydrogels can be used effectively for antimicrobial applications as well as for wound care applications.
Databáze: OpenAIRE
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