The actions of saralasin on the renal circulation of man and dog; evidence for a sympathetic neural component to vasoconstriction
| Autor: | Philip S. Lewis, W. Stanley Peart, Christopher S. Wilcox, Peter S. Sever |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Sympathetic nervous system Sympathetic Nervous System Clinical Biochemistry Vasodilation Essential hypertension Kidney Biochemistry chemistry.chemical_compound Dogs Internal medicine medicine.artery Medicine Animals Humans Renal artery Renal circulation business.industry Angiotensin II General Medicine Middle Aged medicine.disease Denervation medicine.anatomical_structure Endocrinology chemistry Regional Blood Flow Vasoconstriction Renal blood flow Female medicine.symptom business Saralasin |
| Zdroj: | European journal of clinical investigation. 11(2 Suppl 1) |
| ISSN: | 0014-2972 |
| Popis: | The mechanism of renal vasoconstriction produced by saralasin and its dependence on the sympathetic nervous system was investigated in subjects with mild essential hypertension and in anaesthetized dogs. Fluid or saline was given to maximize agonist vasoconstrictor responses. The changes in renal haemodynamics produced by intravenously infused saralasin (dose 0.01-10 microgram kg-1 min-1) were assessed by clearance methods. In the patients, it induced a dose-related renal vasoconstriction which correlated with a rise in plasma noradrenaline levels. In dogs with innervated kidneys it also caused vasoconstriction. But in dogs with denervated kidneys it caused vasodilatation. Infusion at the highest dose directly into the renal artery of denervated kidneys induced only vasodilatation. We conclude that one component of the renal vasoconstriction that occurs with intravenous saralasin infusions is mediated by the renal nerves. |
| Databáze: | OpenAIRE |
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