Epidemic Sindbis Virus Infection in Finland: A Population-Based Case-Control Study of Risk Factors
| Autor: | J. Pekka Nuorti, Sandra Guedes, Jussi Sane, Eija Kela, Satu Kurkela, Peter Klemets, Olli Vapalahti, Outi Lyytikäinen, Jukka Ollgren |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Sindbis virus Adolescent Population 03 medical and health sciences 0302 clinical medicine Risk Factors Animals Humans Immunology and Allergy Medicine 030212 general & internal medicine Child education Finland Aged Aged 80 and over 0303 health sciences education.field_of_study biology Alphavirus Infections 030306 microbiology business.industry Case-control study Infant Insect Bites and Stings Odds ratio Middle Aged biology.organism_classification Rash Confidence interval 3. Good health Culicidae Infectious Diseases Sindbis virus infection Infectious disease (medical specialty) Case-Control Studies Child Preschool Multivariate Analysis Immunology Female Sindbis Virus medicine.symptom business Demography |
| Zdroj: | The Journal of Infectious Diseases. 204:459-466 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jir267 |
| Popis: | Background. Sindbis virus (SINV) is an arthropod-borne alphavirus that causes rash and arthritis. In Finland, epidemics occur cyclically, but factors associated with clinical SINV infection are largely unknown. We conducted a population-based case-control study during the epidemic year 2002. Methods. SINV cases were serologically confirmed and reported to the National Infectious Disease Registry. Five control subjects, matched for age, sex, and residence, were selected from the National Population Information System. Data were collected using a self-administered mail survey. Conditional logistic regression models were used to identify independent risk factors; missing data were addressed using Bayesian full-likelihood modeling. Results. A total of 337 case patients (58% female; age range, 1‐94 y) and 934 control subjects were enrolled. Reported exposure to mosquito bites (matched odds ratio [mOR], 16.7; 95% confidence interval [CI], 9.1‐33.4) and spending time in woods or marshland (mOR, 1.8; 95% CI, 1.3‐2.5) were independently associated with SINV infection in the multivariable model. The population-attributable risk for mosquito bites was 87.2%. There were dose-response relations for increased number of insect bites (mOR, 23.8‐72.5) and increased time spent in woods or marshland (mOR, 1.3‐2.2). Conclusions. Educating the public in endemic areas to avoid mosquito exposure and use protective measures remain important prevention measures for SINV infection. |
| Databáze: | OpenAIRE |
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