Serum biomarker profile orchestrating the seroconversion status of patients with autoimmune diseases upon planned primary 17DD Yellow fever vaccination
| Autor: | Vanessa Peruhype-Magalhães, Licia Maria Henrique da Mota, Valquiria Garcia Dinis, Ana Paula Espíndula Gianordoli, Gisela Freitas Trindade, Francieli Fontana Sutile Tardetti Fantinato, Ana Carolina Campi-Azevedo, Andréa Teixeira-Carvalho, Lídia Balarini da Silva, Ana Paula Neves Burian, Érica Vieira Serrano, Ruben Horst Duque, Maria da Penha Gomes Gouvea, Olindo Assis Martins-Filho, Sávio Carvalho Deotti, Priscila Costa Martins Rocha, Ismael Artur da Costa-Rocha, Maria de Fatima Bissoli, Emily Hime Miranda, Gecilmara Salviato Pileggi, Sonia Alves Gouvea, Maria Bernadete Renoldi de Oliveira Gavi, Lauro Ferreira da Silva Pinto-Neto, Valeria Valim, Sheila Maria Barbosa de Lima, Ketty Lysie Libardi Lira Machado, Samira Tatiyama Miyamoto, Thays Zanon Casagrande, Rafaela Villa Real Barbosa |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
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Autoimmunity Antibodies Viral 0302 clinical medicine Immunogenicity Vaccine 030212 general & internal medicine Prospective Studies Prospective cohort study Aged 80 and over Vaccines Multidisciplinary Vaccination Yellow Fever Vaccine Middle Aged Healthy Volunteers Titer Seroconversion Rheumatoid arthritis Medicine Biomarker (medicine) Cytokines Female Chemokines Yellow fever virus Adult Adolescent Science Immunology Viremia Vaccines Attenuated Article Autoimmune Diseases 03 medical and health sciences Young Adult Plaque reduction neutralization test Yellow Fever medicine Humans Aged 030203 arthritis & rheumatology business.industry medicine.disease Antibodies Neutralizing Case-Control Studies business Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
| ISSN: | 2045-2322 |
| Popis: | The present study aimed to investigate whether the serum biomarkers of immune response orchestrate the seroconversion status in patients with autoimmune diseases (AID) upon planned primary 17DD-YF vaccination. For this purpose a total of 161 individuals were enrolled in a prospective study, including patients with Rheumatoid Arthritis (RA = 38), Spondyloarthritis (SpA = 51), Systemic Lupus Erythematosus (SLE = 21) and Sjögren’s Syndrome (SS = 30) along with a group of healthy controls (HC = 21). Analysis of plaque reduction neutralization test (PRNT) titers and seropositivity rates along with the 17DD-YF viremia and serum biomarkers were carried out at distinct time points (D0/D3–4/D5–6/D7/D14–28). The results demonstrated an overall lower PRNT titer and seropositivity rate (170 vs. 448; 77 vs. 95%) in AID as compared to HC, especially in SpA and SLE subgroups. No significant differences were observed in the viremia levels amongst groups. In general, a more prominent serum biomarker response was observed in AID as compared to HC, throughout the timeline kinetics. Remarkably, AID/PRNT(−) exhibited higher levels of several biomarkers at baseline as compared to AID/PRNT+. Moreover, while AID/PRNT(+) exhibited earlier increase in serum biomarkers at D3–4/D5–6, the AID/PRNT(−) displayed higher response at later time points (D7/D14–D28). Of note, a synchronic increase of IFN-γ at the peak of viremia (D5–6) was observed in HC and AID/PRNT(+) groups, whereas a later asynchronous IFN-γ response was reported for AID/PRNT(−) at D7. The biomarker profile tends to deflate at post-vaccination timeline, highlighting a putative immunomodulatory effect of live attenuated 17DD-YF vaccine in AID/PRNT(+), but not in AID/PRNT(−). Altogether these data suggested that inflammatory status prior vaccination, low IFN-γ at viremia peak and the occurrence of asynchronous biomarker storm after 17DD-YF vaccination may orchestrate the lack of neutralizing antibody response γ. |
| Databáze: | OpenAIRE |
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