Lower Blood Pressure and Gray Matter Integrity Loss in Older Persons
| Autor: | Jessica C. Foster-Dingley, Anne A. van den Berg-Huijsmans, Wouter de Ruijter, Anton J. M. de Craen, Justine E. F. Moonen, Jeroen van der Grond, Roos C. van der Mast |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Endocrinology Diabetes and Metabolism Lower blood pressure Diastole White matter Risk Factors Internal medicine Internal Medicine medicine Humans Arterial Pressure Gray Matter Aged Aged 80 and over medicine.diagnostic_test business.industry Age Factors Magnetic resonance imaging Magnetic Resonance Imaging Original Papers Middle age Surgery Blood pressure medicine.anatomical_structure Diffusion Tensor Imaging Cerebral Small Vessel Diseases Hypertension Cardiology Female Hypotension Cardiology and Cardiovascular Medicine business Diffusion MRI |
| Zdroj: | J Clin Hypertens (Greenwich) Journal of Clinical Hypertension Journal of Clinical Hypertension, 17(8), 630-637 |
| DOI: | 10.1111/jch.12550 |
| Popis: | In contrast to middle age, it is unclear whether blood pressure (BP) in older persons is associated with cerebral small vessel disease (cSVD). The authors evaluated the association of BP with signs of cSVD as well as gray and white matter integrity in older persons. In 220 participants aged 75 years and older from the Discontinuation of Antihypertensive Treatment in the Elderly (DANTE) study, cSVD was assessed with conventional magnetic resonance imaging, and microstructural integrity with diffusion tensor and magnetization transfer (MT) imaging. BP measures were not associated with cSVD. However, lower systolic and diastolic BP and mean arterial pressure were associated with decreased gray matter MT ratio peak height and MT ratio in cortical gray matter. Mean arterial pressure was also associated with increased gray matter diffusivity. A lower level of BP was especially associated with worse gray matter integrity. Results suggest that not only upper but preferably lower thresholds of BP values should be observed in older persons. |
| Databáze: | OpenAIRE |
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