A crystal-structural study of Pauling–Corey rippled sheets
| Autor: | Ariel J. Kuhn, Beatriz Ehlke, Timothy C. Johnstone, Scott R. J. Oliver, Jevgenij A. Raskatov |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Chemical Science. 13:671-680 |
| ISSN: | 2041-6539 2041-6520 |
| DOI: | 10.1039/d1sc05731f |
| Popis: | Following the seminal theoretical work on the pleated β-sheet published by Pauling and Corey in 1951, the rippled β-sheet was hypothesized by the same authors in 1953. In the pleated β-sheet the interacting β-strands have the same chirality, whereas in the rippled β-sheet the interacting β-strands are mirror-images. Unlike with the pleated β-sheet that is now common textbook knowledge, the rippled β-sheet has been much slower to evolve. Much of the experimental work on rippled sheets came from groups that study aggregating racemic peptide systems over the course of the past decade. This includes MAX1/DMAX hydrogels (Schneider), L/D-KFE8 aggregating systems (Nilsson), and racemic Amyloid β mixtures (Raskatov). Whether a racemic peptide mixture is "ripple-genic" ( |
| Databáze: | OpenAIRE |
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