Tissue Doppler Imaging as a Predictor of Immunoglobulin Resistance in Kawasaki Disease
| Autor: | Daniel R Phadke, Mary P. Glode, Heather Heizer, Pei-Ni Jone, Samuel R. Dominguez, Sonali S. Patel, Marsha S. Anderson |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Pathology Colorado Myocarditis Systole Diastole Immunoglobulins Mucocutaneous Lymph Node Syndrome Doppler imaging Ventricular Dysfunction Left hemic and lymphatic diseases Internal medicine medicine Humans Child Receiver operating characteristic business.industry Infant Vascular surgery medicine.disease Echocardiography Doppler Cardiac surgery Child Preschool Pediatrics Perinatology and Child Health Cardiology Female Kawasaki disease Cardiology and Cardiovascular Medicine business |
| Zdroj: | Pediatric Cardiology. 36:1618-1623 |
| ISSN: | 1432-1971 0172-0643 |
| Popis: | Kawasaki disease (KD) is characterized by myocarditis and left ventricular dysfunction during the acute phase of the illness. Despite treatment with intravenous immunoglobulin (IVIG), a significant number of patients are IVIG resistant. We evaluated KD patients in the acute phase of illness using tissue Doppler imaging (TDI) to assess whether myocardial dysfunction may predict IVIG resistance. All patients with acute KD presenting to Children’s Hospital Colorado from February 2007 through March 2014 were included in this study and underwent echocardiograms with TDI evaluation at diagnosis. Patients were divided into two groups: IVIG resistant and IVIG responder. Group differences were assessed using Wilcoxon–Mann–Whitney and Chi-square testing. Receiver operating characteristic (ROC) curve analysis was utilized to determine threshold values of TDI measurements associated with IVIG resistance. Fifty-one age-matched IVIG resistant patients were compared to 51 IVIG responder patients [median age, IQR 44.57 (20.13–77.07) vs. 33.49 (17.30–62.89) months, p < 0.44]. There were significant differences in the septal and mitral early diastolic velocities (E′) (p < 0.001 and p < 0.01), respectively. ROC analysis demonstrated that tricuspid E′ |
| Databáze: | OpenAIRE |
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