Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens
| Autor: | J. M. Boulter, B. K. Jakobsen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Antigen Targeting
Phage display Immunology Antibody Affinity Receptors Antigen T-Cell Peptide Biology Antibodies Autoimmune Diseases Major Histocompatibility Complex Antigen Basic Immunology Neoplasms Immunology and Allergy Humans Bacteriophages Antigens Receptor chemistry.chemical_classification T-cell receptor Cell Membrane Models Immunological Antibodies Monoclonal T lymphocyte Chimeric antigen receptor chemistry Immunotherapy Peptides |
| Zdroj: | Clinical and experimental immunology. 142(3) |
| ISSN: | 0009-9104 |
| Popis: | Summary The recent development of T cell receptor phage display opens up the possibility of engineering human T cell receptors with antibody-like binding properties for cell-surface peptide antigens. In this review we briefly discuss recent developments in molecular targeting of peptide antigens. We then discuss potential clinical applications of engineered high-affinity T cell receptors in autoimmunity and cancer. |
| Databáze: | OpenAIRE |
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