Effects of Hormone Antagonists on Morphological and Biochemical Changes Induced by Hormonal Steroids in the Immature Rat Uterus
| Autor: | Inge Michel, Stanford L. Engel, Russell Hilf, A. Robert Turkheimer, Leonard J. Lerner |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Testosterone propionate
medicine.medical_specialty Nitrogen medicine.drug_class Uterus In Vitro Techniques Biology chemistry.chemical_compound Endocrinology Internal medicine medicine Animals Testosterone Body Weight Antagonist Estrogens DNA Organ Size Androgen Rats medicine.anatomical_structure chemistry Estrogen Androgens Estradiol benzoate RNA Female Progestins NADP Hormone |
| Zdroj: | Endocrinology. 78:111-124 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-78-1-111 |
| Popis: | The effects of the uterotrophic steroids, estradiol benzoate, testosterone propionate and progesterone, and their interaction with the estrogen antagonist, MER-25, and the androgen antagonist, A-norprogesterone, on uterine weight, histology and selected biochemical parameters were studied in immature rats. All 3 hormones increased uterine weight in a dose-response relationship, but only the estrogen induced accumulation of intraluminal fluid. These steroids also increased total uterine RNA and DNA and decreased DNA concentration. RNA concentration was not altered consistently. All these uterotrophic compounds increased glucose-6- phosphate dehydrogenase, TPN-isocitric dehydrogenase and TPN-malic enzyme activity (jumoles TPNH/min/mg DNA). Uterine water and nitrogen concentrations were unaltered by any treatment studied. The 3 hormones induced distinctive alterations in the histology of the immature rat uterus. MER-25 did not alter uterine weight, histology or any of the biochemical end-points studied, with... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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