Sleep calms firing rates
| Autor: | Ya Gao, Gina G. Turrigiano, Juliet Bottorff, Alejandro Torrado Pacheco |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
2019-20 coronavirus outbreak genetic structures Coronavirus disease 2019 (COVID-19) Neuronal firing Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Action Potentials Biology Receptors N-Methyl-D-Aspartate Article 03 medical and health sciences 0302 clinical medicine Homeostatic plasticity medicine Animals Premovement neuronal activity Homeostasis Humans Rats Long-Evans Visual Cortex Neurons Neuronal Plasticity Synaptic scaling General Neuroscience Sleep in non-human animals Rats Electrophysiology 030104 developmental biology Visual cortex medicine.anatomical_structure Hebbian theory nervous system Synapses Developmental plasticity Sleep Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron |
| ISSN: | 1471-0048 |
| Popis: | Summary Homeostatic plasticity is hypothesized to bidirectionally regulate neuronal activity around a stable set point to compensate for learning-related plasticity, but to date only upward firing rate homeostasis (FRH) has been demonstrated in vivo. We combined chronic electrophysiology in freely behaving animals with an eye-reopening paradigm to enhance firing in primary visual cortex (V1) and found that neurons bidirectionally regulate firing rates around an individual set point. Downward FRH did not require N-methyl-D-aspartate receptor (NMDAR) signaling and was associated with homeostatic scaling down of synaptic strengths. Like upward FRH, downward FRH was gated by arousal state but in the opposite direction: it occurred during sleep, not during wake. In contrast, firing rate depression associated with Hebbian plasticity happened independently of sleep and wake. Thus, sleep and wake states temporally segregate upward and downward FRH, which might prevent interference or provide unopposed homeostatic compensation when it is needed most. |
| Databáze: | OpenAIRE |
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