Efficacy of the classic ketogenic and the modified Atkins diets in refractory childhood epilepsy
| Autor: | Hoon Chul Kang, Eun Joo Lee, Jung Rim Yoon, Jeong Tae Kim, Jeong A. Kim, Heung Dong Kim, Joon Soo Lee |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Childhood epilepsy Drug Resistant Epilepsy Pediatrics medicine.medical_specialty animal structures Adolescent Diet therapy medicine.medical_treatment food.diet Ketone Bodies law.invention Diet Carbohydrate-Restricted 03 medical and health sciences 0302 clinical medicine food Double-Blind Method Randomized controlled trial Refractory law medicine Humans 030212 general & internal medicine Child Atkins diet business.industry Infant Confidence interval Treatment Outcome Neurology Tolerability Child Preschool Female Neurology (clinical) Diet Ketogenic business 030217 neurology & neurosurgery Follow-Up Studies Ketogenic diet |
| Zdroj: | Epilepsia. 57:51-58 |
| ISSN: | 0013-9580 |
| DOI: | 10.1111/epi.13256 |
| Popis: | SummaryObjective We aimed to compare the efficacy, safety, and tolerability of a modified Atkins diet (MAD) with the classic ketogenic diet (KD) for the treatment of intractable childhood epilepsy. Methods From March 2011 to March 2014, 104 patients aged 1–18 years who had refractory epilepsy were randomly assigned to each diet group (ClinicalTrials.gov, number NCT2100501). A seizure diary record was used to compare seizure frequencies with the baseline prediet seizure frequency at the third and sixth months after diet therapy initiation. Results Fifty-one patients were assigned to the KD and 53 patients to the MAD. The KD group had a lower mean percentage of baseline seizures compared with the MAD group at 3 months (38.6% for KD, 47.9% for MAD) and 6 months (33.8% for KD, 44.6% for MAD), but the differences were not statistically significant (95% confidence interval [CI] 24.1–50.8, p = 0.291 for 3 months; 95% CI 17.8–46.1, p = 0.255 for 6 months). Instead, for patients aged 1–2 years, seizure outcomes were consistently much more favorable in patients consuming the KD compared with those consuming the MAD. The rate of seizure freedom at 3 months after diet therapy initiation was significantly higher (53% for KD, 20% for MAD, p = 0.047) in these patients. The MAD had advantages with respect to better tolerability and fewer serious side effects. Significance The MAD might be considered as the primary choice for the treatment of intractable epilepsy in children, but the classic KD is more suitable as the first line of diet therapy in patients |
| Databáze: | OpenAIRE |
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