Enhanced post-licensure safety surveillance of a new recombinant acellular pertussis vaccine licensed as a monovalent (aP, Pertagen®) and tetanus, reduced-dose diphtheria combination (TdaP, Boostagen®) vaccine for immunization of adolescents and adults in Thailand
| Autor: | Surasith Chaithongwongwatthana, Anita H. J. van den Biggelaar, Hong Thai Pham, Librada Fortuna, Jane Spiegel, Wassana Wijagkanalan, Ngamphol Soonthornworasiri, Souad Mansouri |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Adolescent Whooping Cough Immunization Secondary Active immunization Diphtheria-Tetanus-acellular Pertussis Vaccines 03 medical and health sciences 0302 clinical medicine Pregnancy 030225 pediatrics Pharmacovigilance medicine Humans 030212 general & internal medicine Adverse effect Child Pertussis Vaccine Tetanus General Veterinary General Immunology and Microbiology business.industry Diphtheria Vaccination Public Health Environmental and Occupational Health medicine.disease Thailand Antibodies Bacterial Infectious Diseases Immunization Molecular Medicine Pertussis vaccine Female business medicine.drug |
| Zdroj: | Vaccine. 38(51) |
| ISSN: | 1873-2518 |
| Popis: | A new generation of recombinant acellular pertussis vaccine containing genetically inactivated pertussis toxin (PTgen) was licensed as a monovalent pertussis vaccine (aPgen; Pertagen®) and in combination with tetanus and reduced-dose diphtheria (TdaPgen; Boostagen®) for active immunization in individuals aged 11 years and older in Thailand in 2016. We here report post-marketing safety data on the use of the vaccines in individuals in the community obtained through active pharmacovigilance surveillance including pregnant women participating in a prospective observational study. Between May 2017 and February 2020 for TdaPgen and between June 2018 and February 2020 for aPgen, participating health care providers vaccinated and collected safety data for 11,429 exposed adolescents and adults. This included 1778 pregnant women. The incidence rate of adverse events following immunization (AEFIs) was 11.5 per 1000 of vaccinated individuals (95% confidence interval (95% CI) 9.7–13.6). AEFIs mostly concerned local pain at the injection site and muscle pain, and symptoms were mild and mostly resolved within a few days with no complications. The incidence rate of AEFIs in women vaccinated during pregnancy was 1.1 per 1000 (95% CI 0.3–4.1). Of 833 pregnant women vaccinated with recombinant aPgen or TdaPgen, 91.4% (95% CI 89.3–93.3) had uncomplicated pregnancies and 98.7% (95% CI 97.7–99.4) of the 855 babies delivered by these women were born healthy, which exceeds rates generally reported in Thailand. There were no vaccine-related serious adverse events reported during the surveillance period. In conclusion, active pharmacovigilance confirms that the recombinant pertussis vaccines aPgen (Pertagen) and TdaPgen (Boostagen) are safe in adolescents and adults, including pregnant women vaccinated in the second or third trimester of pregnancy. |
| Databáze: | OpenAIRE |
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