Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior
| Autor: | Lucie A.L. Descamps, Joanna Y.N. Lau, Moritz O. Buchholz, Brendan A. Bicknell, Christoph Schmidt-Hieber, Rebecca Nutbrown, Nick T.M. Robinson, Lloyd E Russell, Georgy K. Antonov, Michael Häusser |
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| Rok vydání: | 2020 |
| Předmět: |
hippocampus
place cell two-photon calcium imaging Place cell spatial navigation Hippocampus Hippocampal formation Optogenetics Biology two-photon optogenetics Spatial memory Article General Biochemistry Genetics and Molecular Biology memory 03 medical and health sciences 0302 clinical medicine Calcium imaging Episodic memory 030304 developmental biology 0303 health sciences Cognitive map behavior Correction all-optical interrogation inhibition virtual reality Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2020.12.010 |
| Popis: | Summary The hippocampus is crucial for spatial navigation and episodic memory formation. Hippocampal place cells exhibit spatially selective activity within an environment and have been proposed to form the neural basis of a cognitive map of space that supports these mnemonic functions. However, the direct influence of place cell activity on spatial navigation behavior has not yet been demonstrated. Using an ‘all-optical’ combination of simultaneous two-photon calcium imaging and two-photon optogenetics, we identified and selectively activated place cells that encoded behaviorally relevant locations in a virtual reality environment. Targeted stimulation of a small number of place cells was sufficient to bias the behavior of animals during a spatial memory task, providing causal evidence that hippocampal place cells actively support spatial navigation and memory. Graphical Abstract Highlights • Two-photon optogenetics in VR enables targeted manipulation of place cell ensembles • Activating specific place cell ensembles drives their spatially associated behavior • Place cell stimulation inhibits endogenous place code expression and triggers remapping • Direct evidence for a causal role of place cells in spatial navigation Selective stimulation of a small number of hippocampal place cells in mice provides causal evidence that hippocampal place cells actively support spatial navigation and memory. |
| Databáze: | OpenAIRE |
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