Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Granulomatous Inflammation Mimicking High-Grade Malignancy on FDG-PET/CT
| Autor: | Hadyn T. Williams, Darko Pucar, Joyce Hsu, Jayanth Keshavamurthy, Leo Jia |
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| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Neoplasms Carcinoid Tumor Malignancy Granulomatous inflammation Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Biopsy Medicine Humans Radiology Nuclear Medicine and imaging Avidity Pulmonary Neuroendocrine Cell Lung Aged Hyperplasia medicine.diagnostic_test business.industry General Medicine medicine.disease 030228 respiratory system 030220 oncology & carcinogenesis Immunology Immunohistochemistry Multiple Pulmonary Nodules Fdg pet ct Female Radiopharmaceuticals business |
| Zdroj: | Clinical nuclear medicine. 42(1) |
| ISSN: | 1536-0229 |
| Popis: | Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare form of preinvasive lung lesion associated with indolent carcinoid tumor formation. This disease is characterized by multiple small pulmonary nodules with low SUVmax on F-FDG PET. Biopsy and immunohistochemical staining for neuroendocrine markers confirm diagnosis. There is no consensus for treatment, which typically involves surgical excision or management of symptoms with steroid-based therapies. We report an unusual case of DIPNECH colocalizing with necrotizing granulomatous inflammation mimicking high-grade aggressive malignancy on FDG-PET and a typical case of DIPNECH for comparison with low FDG avidity. |
| Databáze: | OpenAIRE |
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