Utility of MRI in the identification of hippocampal sclerosis of aging
| Autor: | Claudia H. Kawas, Zainab Khan, S. Ahmad Sajjadi, Davis C. Woodworth, Hannah L. Nguyen, Maria M. Corrada |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Aging Pathology medicine.medical_specialty Databases Factual Epidemiology Neuropathology Hippocampal formation Hippocampus Article 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Atrophy Developmental Neuroscience Alzheimer Disease medicine Humans Hippocampus (mythology) CA1 Region Hippocampal Aged 030304 developmental biology Aged 80 and over 0303 health sciences Hippocampal sclerosis Sclerosis medicine.diagnostic_test business.industry Health Policy Subiculum Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health nervous system Biomarker (medicine) Female Neurology (clinical) Geriatrics and Gerontology business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Alzheimers Dement |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | INTRODUCTION: Hippocampal sclerosis of aging (HS) is a common pathology often misdiagnosed as Alzheimer’s disease. We tested the hypothesis that participants with HS would have a magnetic resonance imaging (MRI)-detectable hippocampal pattern of atrophy distinct from participants without HS, both with and without Alzheimer’s disease neuropathology (ADNP). METHODS: Query of the National Alzheimer’s Coordinating Center database identified 198 participants with MRI and autopsy. Hippocampal subfields were segmented with FreeSurfer v6. Analysis of covariance for subfield volumes compared HS+ participants to those without HS, both with ADNP (HS−/ADNP+) and without (HS−/ADNP−). RESULTS: HS+ participants (N = 27, 14%) showed atrophied cornu ammonis 1 (CA1; left P < .001, η(p)(2) = 0.14; right P = .001, η(p)(2) = 0.09) and subiculum (left P < .001, η(p)(2) = 0.139; right P = .001, η(p)(2) = 0.085) compared to HS−/ADNP+ (N = 100, 51%). Compared to HS−/ADNP− (N = 71, 36%), HS+ also had atrophy in subiculum (left P < .001, η(p)(2) = 0.235; right P = .002, η(p)(2) = 0.137) and CA1 (left P < .001, η(p)(2) = 0.137; right P = .006, η(p)(2) = 0.070). DISCUSSION: Subiculum and CA1 atrophy from clinical MRI may be a promising in vivo biomarker for HS. |
| Databáze: | OpenAIRE |
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