C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor
| Autor: | Yoshitaka Hamashima, Joshua P. Barham, Hiromichi Odajima, Noriyuki Ohneda, Tadashi Okamoto, Souma Tamaoki, Hiromichi Egami |
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| Rok vydání: | 2018 |
| Předmět: |
Moisture
010405 organic chemistry Organic Chemistry Flow (psychology) Alkylation 010402 general chemistry 01 natural sciences Biochemistry Chemical synthesis 0104 chemical sciences Styrene chemistry.chemical_compound chemistry Chemical engineering Amide SCALE-UP Physical and Theoretical Chemistry Microwave |
| Zdroj: | Organicbiomolecular chemistry. 16(41) |
| ISSN: | 1477-0539 |
| Popis: | C-Alkylation of N-alkylamides with styrenes is reported, proceeding in ambient air/moisture to give arylbutanamides and pharmaceutically-relevant scaffolds in excellent mass balance. Various amide and styrene derivatives were tolerated, rapidly affording molecular complexity in a single step; thus highlighting the future utility of this transformation in the synthetic chemistry toolbox. Reaction scalability (up to 65 g h-1 product) was demonstrated using a Microwave Flow reactor, as the first example of a C-alkylation reaction using styrenes in continuous flow. |
| Databáze: | OpenAIRE |
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