Early Combination Antiretroviral Therapy Limits Exposure to HIV-1 Replication and Cell-Associated HIV-1 DNA Levels in Infants

Autor: R. W. Hudson, Mohan Somasundaran, John L. Sullivan, Eric Mick, Pactg Investigators, Lynne M. Mofenson, Margaret M. McManus, Katherine Luzuriaga
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
RNA viruses
Male
Physiology
lcsh:Medicine
Artificial Gene Amplification and Extension
HIV Infections
Pathology and Laboratory Medicine
Virus Replication
Biochemistry
Polymerase Chain Reaction
law.invention
Persistence (computer science)
Families
White Blood Cells
0302 clinical medicine
Immunodeficiency Viruses
law
Animal Cells
Antiretroviral Therapy
Highly Active
Blood plasma
Medicine and Health Sciences
Medicine
Public and Occupational Health
030212 general & internal medicine
Longitudinal Studies
lcsh:Science
Children
Polymerase chain reaction
Multidisciplinary
T Cells
virus diseases
Hematology
Viral Load
Vaccination and Immunization
3. Good health
Body Fluids
Nucleic acids
Blood
Treatment Outcome
Anti-Retroviral Agents
Medical Microbiology
Viral Pathogens
Child
Preschool
Viruses
RNA
Viral
Female
Pathogens
Anatomy
Cellular Types
Viral load
Infants
Research Article
Cart
DNA Copy Number Variations
Immune Cells
Immunology
Antiretroviral Therapy
DNA replication
Research and Analysis Methods
Peripheral blood mononuclear cell
Microbiology
Blood Plasma
Time-to-Treatment
03 medical and health sciences
Antiviral Therapy
Virology
Retroviruses
Genetics
Humans
Molecular Biology Techniques
Microbial Pathogens
Molecular Biology
Blood Cells
business.industry
lcsh:R
Lentivirus
Organisms
Biology and Life Sciences
HIV
Infant
DNA
Cell Biology
Viral Replication
030104 developmental biology
Viral replication
Age Groups
People and Places
DNA
Viral
HIV-1
Leukocytes
Mononuclear
lcsh:Q
Population Groupings
Preventive Medicine
business
Zdroj: PLoS ONE
PLoS ONE, Vol 11, Iss 4, p e0154391 (2016)
ISSN: 1932-6203
Popis: The primary aim of this study was to measure HIV-1 persistence following combination antiretroviral therapy (cART) in infants and children. Peripheral blood mononuclear cell (PBMC) HIV-1 DNA was quantified prior to and after 1 year of cART in 30 children, stratified by time of initiation (early, age 3 months-2 years, LT). Pre-therapy PBMC HIV-1 DNA levels correlated with pre-therapy plasma HIV-1 levels (r = 0.59, p
Databáze: OpenAIRE
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