The influence of topical dermatological treatment modalities on epidermal Langerhans cells and contact sensitization in mice
| Autor: | Gruner S, Niels Sönnichsen, Dirk Strunk, Angelika Zwirner |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Time Factors
Langerhans cell Administration Topical medicine.medical_treatment Antigen presentation Dermatology Pyrogallol Pharmacology Dermatitis Contact Mice Tar (tobacco residue) Psoriasis Dithranol medicine Ultraviolet light Animals Immunology and Allergy PUVA Therapy Coal Tar Adenosine Triphosphatases Mice Inbred BALB C Chemotherapy business.industry Histocompatibility Antigens Class II Anthralin medicine.disease medicine.anatomical_structure Langerhans Cells Toxicity Immunology business medicine.drug |
| Zdroj: | Contact Dermatitis. 26:241-247 |
| ISSN: | 0105-1873 |
| Popis: | The influence of the widely used topical dermatological treatment modalities anthralin, coal tar and pyrogallol on surface markers of epidermal Langerhans cells and contact sensitization was studied and compared with that of a PUVA treatment. A common effect of all dermatological therapies tested was inhibition of Langerhans cell ATPase, whereas an effect on MHC class II antigens was found only after PUVA or tar treatment. The induction of contact hypersensitivity was inhibited only by PUVA, and not by the other treatments. These results show that various forms of topical therapy influence surface markers and immunological function of epidermal Langerhans cells differently. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text