Role of Tim-3 in regulating tumorigenesis, inflammation, and antitumor immunity therapy
| Autor: | Xianglei He, Yu-Ting Cao, Fang Huang, Qiang Li, Huihui Liu, Yigang Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research Carcinogenesis animal diseases medicine.medical_treatment Inflammation medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Immune system Cancer immunotherapy Interferon Cell Line Tumor Neoplasms Antineoplastic Combined Chemotherapy Protocols Genetics medicine Animals Humans Molecular Targeted Therapy Hepatitis A Virus Cellular Receptor 2 Innate immune system business.industry Cancer General Medicine Immunotherapy medicine.disease Xenograft Model Antitumor Assays Disease Models Animal 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Tumor Escape medicine.symptom business medicine.drug |
| Zdroj: | Cancer biomarkers : section A of Disease markers. 32(2) |
| ISSN: | 1875-8592 |
| Popis: | Over the past decade, cancer immunotherapy, such as immune checkpoint inhibitors (ICRs), has attained considerable progresses in clinical practice. T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) act as next ICRs, and originally function as a co-inhibitory receptor expressed on interferon (IFN)-γ producing CD4+ and CD8+ T-cells. Furthermore, Tim-3 has also been found to express on innate immune cells and several types of tumors, signifying the pivotal role that Tim-3 plays in chronic viral infections and cancer. In addition, Tim-3 and multiple ICRs are concurrently expressed and regulated on dysfunctional or exhausted T-cells, leading to improved antitumor immune responses in preclinical or clinical cancer therapy through co-blockade of Tim-3 and other ICRs such as programmed cell death-1 (PD-1). In this review, the biological characteristics of Tim-3 and the function of Tim-3 in regulating tumorigenesis and inflammation have been summarized. The usage of a single blockade of Tim-3 or in combination with multiple immunotherapy regimens have drawn attention to antitumor potential as a target for immunotherapy. |
| Databáze: | OpenAIRE |
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