Immunologic self tolerance maintained by T-cell-mediated control of self-reactive T cells: implications for autoimmunity and tumor immunity
| Autor: | Shimon Sakaguchi, Noriko Sakaguchi, Sayuri Yamazaki, Yuhshi Kuniyasu, Misako Itoh, Jun Shimizu, Takeshi Takahashi |
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| Rok vydání: | 2001 |
| Předmět: |
CD4-Positive T-Lymphocytes
Cellular immunity T cell Immunology Down-Regulation Autoimmunity Biology medicine.disease_cause Microbiology Immune tolerance Mice Immunity Neoplasms medicine Animals IL-2 receptor Mice Inbred BALB C food and beverages Receptors Interleukin-2 T lymphocyte biochemical phenomena metabolism and nutrition Rats Infectious Diseases medicine.anatomical_structure Self Tolerance |
| Zdroj: | Microbes and infection. 3(11) |
| ISSN: | 1286-4579 |
| Popis: | T-cell-mediated dominant control of self-reactive T cells is one mechanism for maintaining immunologic self tolerance. It also hampers the generation of immunity to autologous tumor cells. Abrogation of the control can evoke potent tumor immunity as well as autoimmunity in normal animals. This common regulatory mechanism for autoimmunity and tumor immunity can be exploited to devise a novel immunotherapy against cancer. |
| Databáze: | OpenAIRE |
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