Cyclin D1/cdk4, estrogen receptors .ALPHA. and .BETA., in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric carcinogenesis: immunohistochemical study
| Autor: | Hiroyuki Takahashi, Hiroshi Hano, Shin Wakui, Masaru Shirai, Tomoko Muto, Masaya Motohashi, Yoshihiko Suzuki |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Oncology Methylnitronitrosoguanidine medicine.medical_specialty Estrogen receptor Adenocarcinoma Toxicology Sex Factors Cyclin D1 Stomach Neoplasms Internal medicine Biomarkers Tumor Gastric mucosa medicine Animals Estrogen Receptor beta Rats Wistar Estrogen receptor beta biology Cyclin-dependent kinase 4 Cell growth Estrogen Receptor alpha Expression index Cyclin-Dependent Kinase 4 Immunohistochemistry Rats medicine.anatomical_structure Gastric Mucosa Carcinogens biology.protein Cancer research Female Estrogen receptor alpha |
| Zdroj: | The Journal of Toxicological Sciences. 36:373-378 |
| ISSN: | 1880-3989 0388-1350 |
| DOI: | 10.2131/jts.36.373 |
| Popis: | Hyperproliferative cell growth due to cyclin D1/cdk4, marker of cellular proliferation, is considered to be regulated by the expression of estrogen receptors (ERs). We investigated the immunohistochemical expression of cyclin D1/cdk4 and ERs in N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced rat gastric carcinogenesis. The gastric cancer incidence and expression of cyclin D1/ckd4 in gastric carcinogenesis were significantly higher in males than females. Although the ERα expression index was similar in both sexes, the ERβ expression in preneoplastic hyperplastic lesions as well as gastric cancers was significantly higher in females than in males. The present study revealed a gender difference in MNNG-induced rat gastric carcinogenesis that seemed to involve the sex difference in cyclin D1/cdk4 expression, and ERβ expression became evident at the preneoplastic promotion stage in gastric carcinogenesis. |
| Databáze: | OpenAIRE |
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