An open-label efficacy trial of escitalopram for night eating syndrome
| Autor: | Andrew B. Newberg, Jacob Dubroff, Stacia K. Studt, Robert I. Berkowitz, Kelly C. Allison, Albert J. Stunkard, Louise Hesson, Reneé H. Moore |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Citalopram Hyperphagia Chronobiology Disorders Night eating syndrome law.invention Feeding and Eating Disorders Randomized controlled trial Quality of life law Binge-eating disorder Internal medicine medicine Insomnia Humans Escitalopram Psychiatry Middle Aged medicine.disease Psychiatry and Mental health Clinical Psychology Eating disorders Treatment Outcome Mood Female medicine.symptom Psychology Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Eating Behaviors. 14:199-203 |
| ISSN: | 1471-0153 |
| Popis: | Objective Night eating syndrome (NES) has become increasingly recognized as a disorder in need of effective treatments. Selective serotonin reuptake inhibitors have shown efficacy in previous trials, so we sought to expand our understanding of the efficacy of escitalopram in the current trial. Method Thirty-one adults with NES participated in a 12-week open-label trial of escitalopram. Outcome measures included the Night Eating Symptom Scale (NESS), percent of daily intake after the evening meal (% intake) and number of nocturnal ingestions/week (NI), weight, total awakenings/week, mood, and quality of life. Mixed-effects models were used to assess change over time. Results Significant reductions were observed from week 0 to week 12 for the NESS (30.2 to 15.2), % intake (46% to 17%), NI (5.8 to 1.2), weight (90.2 to 88.6 kg), awakenings (8.1 to 2.7), and BDI-II (12.1 to 7.7). Outcomes did not differ significantly by gender, age, race, or psychiatric co-morbidity status. Eighteen of 31 completed 12 weeks of treatment. Discussion This open-label trial of escitalopram showed significant reductions in symptoms associated with NES. Randomized controlled trials are warranted to test these findings. Trial Registration: clinicaltrials.gov identifier: NCT01401595 . |
| Databáze: | OpenAIRE |
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