Interplay of Oxidative Stress and Nitric Oxide Synthase Gene Expression on Cardiovascular Responses in Preeclampsia
| Autor: | Anita Herur, Manjunatha Aithala, Kusal K. Das, Ashalata Mallapur, Rajat Hegde, Suyamindra Kulkarni |
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| Rok vydání: | 2022 |
| Předmět: |
preeclampsia/eclampsia
Nitric Oxide Synthase Type III biologia vascular genética molecular Gene Expression Nitric Oxide Synthase Type II Obstetrics and Gynecology vascular biology Nitric Oxide Antioxidants préeclâmpsia/eclâmpsia Oxidative Stress Pre-Eclampsia Pregnancy Case-Control Studies Malondialdehyde molecular genetics Humans Female Nitric Oxide Synthase |
| Zdroj: | Revista Brasileira de Ginecologia e Obstetrícia, Volume: 44, Issue: 3, Pages: 214-219, Published: 27 JUN 2022 Revista Brasileira de Ginecologia e Obstetrícia v.44 n.3 2022 Revista brasileira de ginecologia e obstetrícia Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) instacron:FEBRASGO |
| ISSN: | 1806-9339 0100-7203 |
| DOI: | 10.1055/s-0042-1742313 |
| Popis: | Objective To assess the influence of oxidative stress on the gene expression of nitric oxide synthases (NOS 3 and NOS 2) and, hence, the cardiovascular responses in preeclampsia. Methods This was a case control study in which patients with preeclampsia (PE group) and normal pregnancy controls (NP group) were included according to the guidelines of the American College of Obstetricians and Gynecologists (ACOG). The serum levels of malondialdehyde (MDA), total antioxidant capacity, and nitric oxide (NO) were estimated, and the heart rate andmean arterial pressure were recorded. The gene profiling of NOS3 and NOS2 was performed through real-time polymerase chain reaction (RT-PCR). The statistical analysis was performed using the Student t-test, and values of p |
| Databáze: | OpenAIRE |
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