Effects of parathyroid hormone on exocrine pancreatic secretion in parathyroidectomized dogs
| Autor: | N. Kariv, F. Rolant, Gur Ben-Ari, J. Haspel, E. S. Klein |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Physiology Bicarbonate chemistry.chemical_element Parathyroid hormone Calcium Biochemistry Parathyroid Glands chemistry.chemical_compound Dogs Pancreatic Juice Secretin Internal medicine medicine Animals Secretion skin and connective tissue diseases Pancreas Pancreatic duct Bicarbonates Kinetics medicine.anatomical_structure Endocrinology chemistry Parathyroid Hormone Pancreatic juice Duodenum Gastric acid sense organs hormones hormone substitutes and hormone antagonists |
| Zdroj: | Archives internationales de physiologie et de biochimie. 89(2) |
| ISSN: | 0003-9799 |
| Popis: | The effects of intravenous parathyroid hormone (PTH) on steady state Secretin-induced pancreatic secretion were studied in seven dogs before and after parathyroidectomy. Free flow of pancreatic juice was obtained by direct cannulation of the main pancreatic duct (the minor duct being ligated) : a gastric fistula prevented the entry of gastric acid into the duodenum. In the normal dog PTH caused a significant increase in volume and bicarbonate concentration, reciprocal change in chloride and no change in total protein concentration. The stimulatory effect of PTH was dose-dependent. In the parathyroidectomized dog, the basic Secretin-induced secretion was lower than the preoperative values, but PTH infusion caused a significant increase in volume of fluids and bicarbonate concentration, reciprocal change in chloride and no change in protein concentration. These results were not dependent on calcium blood level, and did not change after calcium injection to the hypocalcemic parathyroidectomized dog. It is suggested, that PTH may have a direct effect on pancreatic exocrine secretion. |
| Databáze: | OpenAIRE |
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