Arthritis Induced by Adjuvant in Spontaneously Hypertensive and Normotensive Rats: Endogenous Glucocorticoid Effects on Inflammatory Response
| Autor: | Silvana Martins Caparroz-Assef, Ciomar Aparecida Bersani-Amado, Micheli G. Torres, Roberto Kenji Nakamura Cuman, Emy Luiza Ishii-Iwamoto, Fábio H. Kwasniewski, Luís G. Scaliante |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Freund's Adjuvant Immunology Arthritis Spleen Inflammation Rats Inbred WKY Reference Values Rats Inbred SHR Internal medicine Edema medicine Animals Immunology and Allergy Rats Wistar Glucocorticoids business.industry Adrenalectomy Body Weight medicine.disease Arthritis Experimental Rats medicine.anatomical_structure Endocrinology Freund's adjuvant Hypertension Lymph medicine.symptom business Glucocorticoid medicine.drug |
| Zdroj: | Inflammation. 32:20-26 |
| ISSN: | 1573-2576 0360-3997 |
| Popis: | The present study investigated arthritis induced by complete Freund adjuvant (AIA) in spontaneously hypertensive and normotensive rats (respectively, SHR and NTR rats). The inflammatory reaction was studied for 28 days by evaluating paw edema and secondary lesions found 10 days after complete Freund adjuvant (CFA) administration. The body weight of the animals and macroscopic alterations of several organs, including spleen, thymus, adrenal glands, and lymph nodes, were also analyzed. The results showed that the AIA manifestations were decreased in SHRs compared with NTRs. Moreover, this altered inflammatory response was not modified by surgical adrenalectomy. |
| Databáze: | OpenAIRE |
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