Acoustic Simulation for Transcranial Focused Ultrasound Using GAN-Based Synthetic CT
| Autor: | Heekyung Koh, Jong-Hwan Lee, Yong-An Chung, Hyung-Min Kim, Tae Young Park |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.diagnostic_test
business.industry Image quality Skull Significant difference Magnetic resonance imaging Acoustics Magnetic Resonance Imaging Focused ultrasound Computer Science Applications medicine.anatomical_structure Health Information Management Sørensen–Dice coefficient medicine Humans Computer Simulation Density ratio Electrical and Electronic Engineering Tomography X-Ray Computed business Sound pressure Nuclear medicine Biotechnology |
| Zdroj: | IEEE Journal of Biomedical and Health Informatics. 26:161-171 |
| ISSN: | 2168-2208 2168-2194 |
| DOI: | 10.1109/jbhi.2021.3103387 |
| Popis: | Transcranial focused ultrasound (tFUS) is a promising non-invasive technique for treating neurological and psychiatric disorders. One of the challenges for tFUS is the disruption of wave propagation through the skull. Consequently, despite the risks associated with exposure to ionizing radiation, computed tomography (CT) is required to estimate the acoustic transmission through the skull. This study aims to generate synthetic CT (sCT) from T1-weighted magnetic resonance imaging (MRI) and investigate its applicability to tFUS acoustic simulation. We trained a 3D conditional generative adversarial network (3D-cGAN) with 15 subjects. We then assessed image quality with 15 test subjects: mean absolute error (MAE) = 85.72± 9.50 HU (head) and 280.25±24.02 HU (skull), dice coefficient similarity (DSC) = 0.88±0.02 (skull). In terms of skull density ratio (SDR) and skull thickness (ST), no significant difference was found between sCT and real CT (rCT). When the acoustic simulation results of rCT and sCT were compared, the intracranial peak acoustic pressure ratio was found to be less than 4%, and the distance between focal points less than 1 mm. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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