Cryopreserved amniotic membrane and umbilical cord particulate for managing pain caused by facet joint syndrome

Autor: Daniel S. Bennett
Rok vydání: 2019
Předmět:
Adult
Male
musculoskeletal diseases
medicine.medical_specialty
facet joint syndrome
Treatment outcome
Observational Study
Umbilical cord
Zygapophyseal Joint
Cryopreservation
Injections
Intra-Articular

Umbilical Cord
03 medical and health sciences
0302 clinical medicine
Managing pain
facet joint
medicine
Back pain
Humans
Pain Management
Amnion
030212 general & internal medicine
Aged
Monitoring
Physiologic

Pain Measurement
Retrospective Studies
intra-articular injection
Biological Products
amniotic membrane
business.industry
General Medicine
Middle Aged
musculoskeletal system
lower back pain
Surgery
Treatment Outcome
Chronic disease
medicine.anatomical_structure
Facet joint syndrome
030220 oncology & carcinogenesis
Chronic Disease
Female
medicine.symptom
business
Low Back Pain
Research Article
Zdroj: Medicine
ISSN: 1536-5964
0025-7974
Popis: Treatment of back pain due to facet joint syndrome has been a challenge for physicians since its recognition ∼80 years ago. Intra-articular injections of steroids, local anesthetics, and phenol have been widely adopted despite their known shortcomings. Recently, intra-articular injection of amniotic membrane-umbilical cord (AMUC) has been utilized in various orthopedic indications, including those involving synovial joints, due to its reported anti-inflammatory properties. Herein, use of AMUC for facet joint syndrome was evaluated. A single-center case series was conducted on patients presenting with pain caused by facet joint syndrome, confirmed by single blocking anesthetic injection and treated using a single intra-articular injection of 50 mg particulate AMUC (CLARIX FLO) suspended in preservative-free saline. Patient reported back pain severity (numerical scale 0–10) and opioid use were compared between baseline and 6 months following treatment. A total of 9 patients (7 males, 2 females), average age 52.1 ± 15.9 years, were included. Five patients with cervical pain had a history of trauma, 1 patient had suffered lumbar facet injury and 3 had degenerative lumbar facet osteoarthritis. All patients had severe pain prior to injection (8.2 ± 0.8) and 4 (44%) were taking opioids (>100 morphine milligram equivalents). Six-month post-treatment, average pain had decreased to 0.4 ± 0.7 (P
Databáze: OpenAIRE