Human Parechovirus-3 Encephalitis in Two Neonates: Acute and Follow-Up Magnetic Resonance Imaging and Evaluation of Central Nervous System Markers of Inflammation
| Autor: | Brian Livingston, Carol A. McCarthy, Amanda D. Brownell, Thomas Q. Reynolds |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Parechovirus chemistry.chemical_compound Cerebrospinal fluid Developmental Neuroscience Enterovirus Infections medicine Humans Neurochemistry Inflammation biology Neonatal sepsis medicine.diagnostic_test business.industry Human parechovirus Neopterin Magnetic resonance imaging medicine.disease biology.organism_classification Magnetic Resonance Imaging Neurology chemistry Child Preschool Pediatrics Perinatology and Child Health Encephalitis Neurology (clinical) business Follow-Up Studies |
| Zdroj: | Pediatric Neurology. 52:245-249 |
| ISSN: | 0887-8994 |
| DOI: | 10.1016/j.pediatrneurol.2014.09.019 |
| Popis: | BACKGROUND: Human parechovirus-3 has been known to cause neonatal sepsis and encephalitis for nearly a decade. However, information about magnetic resonance imaging and cerebrospinal fluid findings as well as outcomes has been limited. PATIENTS: Acute presentations and diagnostic testing of two neonates with Human parechovirus-3 encephalitis are described. Clinical and radiographic follow-up is provided. CONCLUSIONS: Evaluation of central nervous system neurochemistry with inflammatory markers such as neopterin, may be helpful for diagnosis in neonatal encephalitis. The pattern of white matter injury seen in these two patients should raise suspicion for Human parechovirus-3 infection. Testing for this virus should be more routinely considered in neonates presenting with encephalitis and normal cerebrospinal fluid results. The severity of radiographic abnormality may not correlate with long-term findings as the clinical and radiographic follow-up after a year is better than expected in the first patient. |
| Databáze: | OpenAIRE |
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