In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium
| Autor: | Bibiana D. Riquelme, Horacio V. Castellini, Nicolás A. Alet, Analía I. Alet, Marcus V. Batista da Silva |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Erythrocytes Microcirculation disorders Remifentanil 030204 cardiovascular system & hematology Pharmacology Biochemistry Microcirculation 03 medical and health sciences Young Adult 0302 clinical medicine Elastic Modulus Erythrocyte Deformability medicine Humans Propofol Cytoskeleton Whole blood Vecuronium Bromide Chemistry Viscosity Erythrocyte Membrane Cell Biology In vitro Analgesics Opioid Red blood cell 030104 developmental biology medicine.anatomical_structure Hemorheology Cardiology and Cardiovascular Medicine Anesthetics Intravenous medicine.drug Neuromuscular Nondepolarizing Agents |
| Zdroj: | Microvascular research. 135 |
| ISSN: | 1095-9319 |
| Popis: | Several studies report flow disturbance and microcirculation disorders upon anesthesia treatment. These alterations are often related to blood rheology changes. In this work, it was attempted to make a detailed description of the alterations in erythrocyte mechanical properties by the action of propofol, remifentanil, and vecuronium. For this, an in vitro study was performed on red blood cell samples from healthy donors incubated with solutions of propofol (4 μg/ml whole blood), remifentanil (10 ng/ml plasma), and vecuronium (0.15 μg/ml plasma). Erythrocyte viscoelastic parameters were determined by octuplicate using a Reometro Eritrocitario. Also, a Wilcoxon signed rank-test with Yates correction for continuity was performed to analyze the overall alteration in the mechanical properties of erythrocytes. Statistical analysis showed that the three studied anesthetics changed the erythrocyte mechanical properties at different parts of the membrane. These results would imply an interaction of these anesthetics with the erythrocyte membrane. Finally, this could conduce to alterations in microcirculation. |
| Databáze: | OpenAIRE |
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