Predictive Factors for Visual Field Conversion
| Autor: | Friedrich E. Kruse, Wolfgang A. Schrems, Robert Laemmer, Laura M. Schrems-Hoesl, Christian Y. Mardin, Folkert K. Horn, Theresa Diekmann |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Retinal Ganglion Cells Intraocular pressure medicine.medical_specialty genetic structures Vision Disorders Glaucoma Scanning laser polarimetry Ocular hypertension Tonometry Ocular 03 medical and health sciences Nerve Fibers 0302 clinical medicine Predictive Value of Tests Positive predicative value Ophthalmology medicine Humans False Positive Reactions Intraocular Pressure Aged Retrospective Studies business.industry Middle Aged medicine.disease eye diseases Visual field medicine.anatomical_structure Scanning Laser Polarimetry Predictive value of tests 030221 ophthalmology & optometry Visual Field Tests Female Ocular Hypertension sense organs Visual Fields business Glaucoma Open-Angle Tomography Optical Coherence 030217 neurology & neurosurgery Follow-Up Studies Optic disc |
| Zdroj: | Journal of Glaucoma. 27:157-163 |
| ISSN: | 1057-0829 |
| Popis: | PURPOSE The purpose of this study was to compare the ability of scanning laser polarimetry (SLP) and spectral-domain optical coherence tomography (SD-OCT) to predict future visual field conversion of subjects with ocular hypertension and early glaucoma. METHODS All patients were recruited from the Erlangen glaucoma registry and examined using standard automated perimetry, 24-hour intraocular pressure profile, and optic disc photography. Peripapillary retinal nerve fiber layer thickness (RNFL) measurements were obtained by SLP (GDx-VCC) and SD-OCT (Spectralis OCT). Positive and negative predictive values (PPV, NPV) were calculated for morphologic parameters of SLP and SD-OCT. Kaplan-Meier survival curves were plotted and log-rank tests were performed to compare the survival distributions. Contingency tables and Venn-diagrams were calculated to compare the predictive ability. RESULTS The study included 207 patients-75 with ocular hypertension, 85 with early glaucoma, and 47 controls. Median follow-up was 4.5 years. A total of 29 patients (14.0%) developed visual field conversion during follow-up. SLP temporal-inferior RNFL [0.667; 95% confidence interval (CI), 0.281-0.935] and SD-OCT temporal-inferior RNFL (0.571; 95% CI, 0.317-0.802) achieved the highest PPV; nerve fiber indicator (0.923; 95% CI, 0.876-0.957) and SD-OCT mean (0.898; 95% CI, 0.847-0.937) achieved the highest NPV of all investigated parameters. The Kaplan-Meier curves confirmed significantly higher survival for subjects within normal limits of measurements of both devices (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|